Claim CB010.2:
The most primitive cells are too complex to have come together by chance. 
(See also Probability of abiogenesis.)
Source:
Watchtower Bible and Tract Society. 1985. Life--How Did It Get Here?
 Brooklyn, NY,
 pg. 44.
Morris, Henry M. 1985. Scientific Creationism. Green Forest, AR:
 Master Books,
 pp. 59-69.
Response:
-  Biochemistry is not chance.  It inevitably produces complex products.
   Amino acids and other complex molecules are even known to form in
   space.
 -  Nobody knows what the most primitive cells looked like.  All the cells
   around today are the product of billions of years of evolution.  The
   earliest self-replicator was likely very much simpler than anything
   alive today; self-replicating molecules need not be all that complex
   (Lee et al. 1996), and protein-building systems can also be simple
   (Ball 2001; Tamura and Schimmel 2001).
 -  This claim is an example of the argument from
 incredulity.
   Nobody denies that the origin of life is an extremely difficult
   problem.  That it has not been solved, though, does not mean it is
   impossible.  In fact, there has been much work in this area, leading to
   several possible origins for life on earth:
-  Panspermia, which says life came from someplace other than earth.
     This theory, however, still does not answer how the first life arose.
 -  Proteinoid microspheres (Fox 1960, 1984; Fox and Dose 1977; Fox et
     al. 1995; Pappelis and Fox 1995):  This theory gives a plausible
     account of how some replicating structures, which might well be
     called alive, could have arisen.  Its main difficulty is explaining
     how modern cells arose from the microspheres.
 -  Clay crystals (Cairn-Smith 1985):  This says that the first
     replicators were crystals in clay.  Though they do not have a
     metabolism or respond to the environment, these crystals carry
     information and reproduce.  Again, there is no known mechanism for
     moving from clay to DNA.
 -  Emerging hypercycles:  This proposes a gradual origin of the first
     life, roughly in the following stages: (1) a primordial soup of
     simple organic compounds.  This seems to be almost inevitable; (2)
     nucleoproteins, somewhat like modern tRNA (de Duve 1995a) or peptide
     nucleic acid (Nelson et al. 2000), and semicatalytic; (3)
     hypercycles, or pockets of primitive biochemical pathways that
     include some approximate self-replication; (4) cellular hypercycles,
     in which more complex hypercycles are enclosed in a primitive
     membrane; (5) first simple cell.  Complexity theory suggests that the
     self-organization is not improbable.  This view of abiogenesis is the
     current front-runner.
 -  The iron-sulfur world (Russell and Hall 1997;
     Wächtershäuser 2000): It has been found that all the steps
     for the conversion of carbon monoxide into peptides can occur at high
     temperature and pressure, catalyzed by iron and nickel sulfides.
     Such conditions exist around submarine hydrothermal vents.  Iron
     sulfide precipitates could have served as precursors of cell walls as
     well as catalysts (Martin and Russell 2003).  A peptide cycle, from
     peptides to amino acids and back, is a prerequisite to metabolism,
     and such a cycle could have arisen in the iron-sulfur world (Huber et
     al. 2003).
 -  Polymerization on sheltered organophilic surfaces (Smith et al.
     1999):  The first self-replicating molecules may have formed within
     tiny indentations of silica-rich surfaces so that the surrounding
     rock was its first cell wall.
 -  Something that no one has thought of yet.
 
 
Links:
Robinson, Richard. 2005.  Jump-starting a cellular world: Investigating
 the origin of life, from soup to networks.  PLoS Biology 3(11): e396.
 http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0030396
References:
-  Ball, Philip. 2001.  Missing links made simple.  Nature Science
   Update (15 Mar.).  http://www.nature.com/nsu/010308/010308-5.html
 -  Cairn-Smith, A. G. 1985. Seven Clues to the Origin of Life,
   Cambridge University Press.
 -  de Duve, Christian. 1995a.  The beginnings of life on
   earth.  American Scientist 83: 428-437.
   http://www.americanscientist.org/template/AssetDetail/assetid/21438?fulltext=true
 -  Fox, S. W. 1960. How did life begin? Science 132: 200-208.
 -  Fox, S. W. 1984. Creationism and evolutionary protobiogenesis.  In:
   Science and Creationism, ed. A. Montagu, Oxford
   University Press, pp. 194-239.
 -  Fox, S. W. and K. Dose. 1977.  Molecular Evolution and the Origin of
   Life, Revised ed.  New York: Marcel Dekker.
 -  Fox, S. W. et al. 1995.  Experimental retracement of the origins of a
   protocell: It was also a protoneuron.  In Ponnamperuma, C. and J.
   Chela-Flores, pp. 17-36.
 -  Huber, Claudia, Wolfgang Eisenreich, Stefan Hecht and Günter
   Wächtershäuser.  2003.  A possible primordial peptide cycle.
   Science 301: 938-940.
 -  Lee, D. H. et al. 1996. A self-replicating peptide. Nature 382:
   525-528.
 -  Martin, W. and M. J. Russell. 2003.  (see below)
 -  Nelson, Kevin E., M. Levy and S. L. Miller. 2000.  Peptide nucleic acids
   rather than RNA may have been the first genetic molecule.  Proceedings of
 the National Academy of Science USA 97:
   3868-3871.
 -  Ponnamperuma, C. and J. Chela-Flores (eds.). 1995.  Chemical
   Evolution: Structure and Model of the First Cell.  Dordrecht: Kluwer
   Academic Publishers.
 -  Pappelis, A. and S. W. Fox. 1995.  Domain protolife: Protocells and
    metaprotocells within thermal protein matrices.  In Ponnamperuma, C. and
    Chela-Flores, pp. 129-132.
 -  Russell, M. J. and A. J. Hall. 1997.  The emergence of life from iron
    monosulphide bubbles at a submarine hydrothermal redox and pH front.
    Journal of the Geological Society of London 154: 377-402.
    http://www.gla.ac.uk/Project/originoflife/html/2001/pdf_articles.htm
 -  Smith, J. V., F. P. Arnold Jr., I. Parsons, and M. R. Lee. 1999.
    Biochemical evolution III: Polymerization on organophilic silica-rich
    surfaces, crystal-chemical modeling, formation of first cells, and
    geological clues.  Proceedings of the National Academy of Science
 USA 96(7): 3479-3485.
    http://www.pnas.org/cgi/content/full/96/7/3479
 -  Tamura, K. and P. Schimmel. 2001. Oligonucleotide-directed peptide
   synthesis in a ribosome- and ribozyme-free system. Proceedings of the
 National Academy of Science USA 98: 1393-1397.
 -  Wächtershäuser, Günter. 2000.  Life as we don't know
    it.  Science 289: 1307-1308.
 
 
Further Reading:
Fry, Iris. 2000.  The Emergence of Life on Earth: A Historical and
 Scientific Overview.  New Brunswick, NJ: Rutgers University Press.
 Cohen, Phil. 1996.  Let there be life.  New Scientist 151 (6 July):
 22-27.  http://www.newscientist.com/hottopics/astrobiology/letthere.jsp
de Duve, Christian. 1995a. 
 (see above)
de Duve, Christian. 1995b.  Vital Dust: Life as a cosmic
 imperative.
 New York: Basic Books.
 Fox, S. 1988.  The Emergence of Life: Darwinian Evolution from the
 Inside.  New York: Basic Books.
 Lacey, J. C., N. S. Wickramasinghe, and G. W. Cook. 1992. Experimental
 studies on the origin of the genetic code and the process of protein
 synthesis: A review update.  Origins of Life and Evolution of the
 Biosphere 22(5): 243-275. (technical)
Lewis, Ricki. 1997.  Scientists debate RNA's role at beginning
 of life on earth.  The Scientist 11(7) (31 Mar.): 11. 
 http://www.the-scientist.com/yr1997/mar/research_970331.html
 (registration required), or
 http://www.mhhe.com/biosci/genbio/life/articles/article28.mhtml
 Martin, W. and M. J. Russell. 2003. On the origins of cells: A hypothesis
 for the evolutionary transitions from abiotic geochemistry to
 chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells.
 Philosophical Transactions, Biological Sciences 358: 59-85.
 (technical)
 McClendon, John H. 1999. The origin of life. Earth-Science Reviews 47:
 71-93. (technical)
 Orgel, L. E. 1994.  The origin of life on the earth.  Scientific
 American 271(4) (Oct):
 76-83.
 Pigliucci, Massimo. 1999. Where do we come from? a humbling look at the
 biology of life's origin. Skeptical Inquirer 23(5): 21-27.
Russell, Michael. 2003.  Evolution: Five big questions: 1. How
 did life begin?  New Scientist 178(2399) (14 June): 33-34.
 Willis, Peter. 1997.  Turning a corner in the search for the origin of
 life.  Santa Fe Institute Bulletin 12(2). 
 http://www.santafe.edu/sfi/publications/Bulletins/bulletin-summer97/turning.html
created  2001-3-31, modified  2005-12-14